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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN2
All Species:
51.52
Human Site:
S157
Identified Species:
80.95
UniProt:
Q9H0D6
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0D6
NP_036387.2
950
108582
S157
E
I
K
E
R
F
D
S
N
C
I
T
P
G
T
Chimpanzee
Pan troglodytes
XP_514546
950
108522
S157
E
I
K
E
R
F
D
S
N
C
I
T
P
G
T
Rhesus Macaque
Macaca mulatta
XP_001094734
961
109718
S157
E
I
K
E
R
F
D
S
N
C
I
T
P
G
T
Dog
Lupus familis
XP_534324
950
108331
S157
E
I
K
E
R
F
D
S
N
C
I
T
P
G
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBR1
951
108669
S157
E
I
K
E
R
F
D
S
N
C
I
T
P
G
T
Rat
Rattus norvegicus
NP_001102066
561
63850
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505862
950
108030
S157
E
V
K
E
R
F
D
S
N
C
I
T
P
G
T
Chicken
Gallus gallus
Q5ZIP4
949
108524
S157
E
V
K
E
R
F
D
S
N
C
I
T
P
G
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM71
908
103942
S159
E
K
G
E
H
F
D
S
N
C
I
T
P
G
T
Honey Bee
Apis mellifera
XP_392371
860
99367
S158
P
K
E
E
H
F
D
S
N
C
I
T
P
G
T
Nematode Worm
Caenorhab. elegans
Q9U299
975
110109
S158
K
E
E
A
H
F
D
S
N
C
I
T
P
G
T
Sea Urchin
Strong. purpuratus
XP_795068
1073
120270
S148
A
K
E
S
H
F
D
S
N
C
I
T
P
G
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FQ03
1020
116807
S157
V
D
S
Q
V
F
D
S
N
V
I
T
P
G
T
Baker's Yeast
Sacchar. cerevisiae
Q02792
1006
115915
S157
R
N
K
K
T
W
D
S
N
A
I
T
P
G
T
Red Bread Mold
Neurospora crassa
Q8WZX5
1072
118291
S163
V
V
K
K
A
F
D
S
N
S
I
T
P
G
T
Conservation
Percent
Protein Identity:
100
99.7
97.6
98
N.A.
96
56.2
N.A.
91.1
82.9
N.A.
N.A.
N.A.
51.2
54
50.5
52.5
Protein Similarity:
100
99.8
98
99
N.A.
97
57.6
N.A.
95.4
90.5
N.A.
N.A.
N.A.
63.2
66.5
63.7
63.4
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
93.3
93.3
N.A.
N.A.
N.A.
80
73.3
66.6
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
0
N.A.
100
100
N.A.
N.A.
N.A.
80
80
80
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.6
40.5
40.8
Protein Similarity:
N.A.
N.A.
N.A.
58
57.4
56.1
P-Site Identity:
N.A.
N.A.
N.A.
60
60
66.6
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
73.3
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
7
0
0
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
74
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
94
0
0
0
0
0
0
0
0
% D
% Glu:
54
7
20
60
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
87
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
7
0
0
0
0
0
0
0
0
0
0
94
0
% G
% His:
0
0
0
0
27
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
34
0
0
0
0
0
0
0
0
94
0
0
0
0
% I
% Lys:
7
20
60
14
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
0
0
0
94
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
0
0
94
0
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
47
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
7
7
0
0
0
94
0
7
0
0
0
0
0
% S
% Thr:
0
0
0
0
7
0
0
0
0
0
0
94
0
0
94
% T
% Val:
14
20
0
0
7
0
0
0
0
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _